Homologous recombination deficient tumor

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• Homologous recombination — Figure 1. During meiosis, homologous recombination can produce new combinations of genes as shown here between similar but not identical copies of human chromosome 1. Homologous recombination is a type of genetic recombination in which nucleotide …   Wikipedia

• Non-homologous end joining — (NHEJ) is a pathway that repairs double strand breaks in DNA. NHEJ is referred to as non homologous because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a… …   Wikipedia

• DNA repair — For the journal, see DNA Repair (journal). DNA damage resulting in multiple broken chromosomes DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human… …   Wikipedia

• PARP1 — Poly (ADP ribose) polymerase 1 PDB rendering based on 1uk0 …   Wikipedia

• p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP …   Wikipedia

• Gene — For a non technical introduction to the topic, see Introduction to genetics. For other uses, see Gene (disambiguation). This stylistic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). The… …   Wikipedia

• Cellular differentiation — Cell differentiation redirects here. For the journal, see Cell Differentiation (journal). In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation… …   Wikipedia

• Transformation (genetics) — An unrelated process called malignant transformation occurs in the progression of cancer. In molecular biology transformation is the genetic alteration of a cell resulting from the direct uptake, incorporation and expression of exogenous genetic… …   Wikipedia

• NSG mouse — NSG, or NOD scid gamma, (NOD.Cg Prkdcscid Il2rgtm1Wjl/SzJ) is among the most immunodeficient strains of inbred laboratory mice described to date.[1] NSG mice lack mature T cells, B cells, and natural killer (NK) cells.[2] NSG mice are also… …   Wikipedia